Une \u00e9quipe de l\u2019Inserm et de Nantes Universit\u00e9, en collaboration avec des \u00e9quipes am\u00e9ricaines (non pr\u00e9cis\u00e9es), annonce avoir mis au point une nouvelle m\u00e9thode de culture permettant de produire, pour la premi\u00e8re fois, des organo\u00efdes intestinaux humains fonctionnels de grande taille. Ces organo\u00efdes sont obtenus \u00e0 partir de cellules souches, se d\u00e9veloppent deux fois plus rapidement qu\u2019avec les m\u00e9thodes existantes et sont capables de g\u00e9n\u00e9rer leurs propres cellules nerveuses. Les r\u00e9sultats ont \u00e9t\u00e9 publi\u00e9s dans la revue scientifique Nature Biomedical Engineering.<\/p>\n
Les organo\u00efdes ainsi produits reproduisent certaines caract\u00e9ristiques structurales et fonctionnelles des tissus intestinaux humains et incorporent un syst\u00e8me nerveux fonctionnel. La m\u00e9thode d\u00e9velopp\u00e9e vise \u00e0 mieux mimer in vitro les conditions du d\u00e9veloppement embryonnaire et \u00e0 limiter le recours \u00e0 une greffe dans un mod\u00e8le animal pour atteindre un stade de d\u00e9veloppement avanc\u00e9, ce qui constituait jusqu\u2019ici une limite importante des approches disponibles.<\/p>\n
Les travaux sont conduits par l\u2019\u00e9quipe de Maxime Mah\u00e9, charg\u00e9 de recherche Inserm au laboratoire \u00ab Le syst\u00e8me nerveux ent\u00e9rique dans les maladies digestives et du cerveau \u00bb (TENS \u2013 Inserm\/Nantes Universit\u00e9). Le contexte mentionn\u00e9 est l\u2019augmentation du nombre de personnes souffrant de maladies gastro-intestinales, pour lesquelles ces organo\u00efdes constituent des outils de recherche destin\u00e9s \u00e0 mieux comprendre le d\u00e9veloppement cellulaire et les m\u00e9canismes pathologiques. L\u2019article souligne que cette avanc\u00e9e ouvre des perspectives pour l\u2019\u00e9tude des maladies gastro-intestinales et le d\u00e9veloppement d\u2019applications th\u00e9rapeutiques futures, sans cependant d\u00e9tailler de calendrier ni de modalit\u00e9s de transfert vers la clinique. Les incertitudes portent ainsi sur le stade de maturit\u00e9 de ces applications et sur les conditions d\u2019une \u00e9ventuelle utilisation clinique ou industrielle.\u00a0(contenu r\u00e9sum\u00e9 en fran\u00e7ais par l’IA)\u200bLire la Suite<\/a>\u200b<\/p>","protected":false},"excerpt":{"rendered":" Une \u00e9quipe de l\u2019Inserm et de Nantes Universit\u00e9, en collaboration avec des \u00e9quipes am\u00e9ricaines (non pr\u00e9cis\u00e9es), annonce avoir mis au point une nouvelle m\u00e9thode de culture permettant de produire, pour 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