Des pharmaciens de l\u2019h\u00f4pital psychiatrique du Vinatier (France) m\u00e8nent le projet \u00ab \u00c9tudes de Stabilit\u00e9 des M\u00e9dicaments Reconditionn\u00e9s \u00bb (ESMR), visant \u00e0 produire des donn\u00e9es scientifiques sur la stabilit\u00e9 de certains psychotropes apr\u00e8s d\u00e9conditionnement, dans le contexte de la dispensation nominative automatis\u00e9e \u00e0 l\u2019h\u00f4pital. Cette modalit\u00e9 de dispensation, assur\u00e9e au Vinatier par deux automates de reconditionnement, impose de retirer les m\u00e9dicaments de leur conditionnement primaire avant leur reconditionnement individuel. En l\u2019absence de donn\u00e9es compl\u00e8tes pour la pharmacop\u00e9e, les pharmaciens appliquent actuellement des dur\u00e9es de conservation prudentes, ce qui s\u00e9curise la prise en charge m\u00e9dicamenteuse mais peut g\u00e9n\u00e9rer des contraintes organisationnelles et un gaspillage potentiel de m\u00e9dicaments.<\/p>\n
L\u2019\u00e9tude porte sur des m\u00e9dicaments couramment utilis\u00e9s en psychiatrie : comprim\u00e9s d\u2019aripiprazole (antipsychotique), sous forme classique et orodispersible, ainsi que g\u00e9lules de sertraline (antid\u00e9presseur ISRS). Leur stabilit\u00e9 physique et chimique est suivie pendant six mois, dans diverses conditions de conservation reproduisant celles de la pr\u00e9paration automatis\u00e9e des doses \u00e0 administrer ainsi que des conditions ambiantes. Plusieurs centaines de comprim\u00e9s ont \u00e9t\u00e9 mobilis\u00e9es pour r\u00e9aliser les essais.<\/p>\n
Le projet associe plusieurs acteurs publics : l\u2019\u00e9quipe pharmaceutique de l\u2019h\u00f4pital du Vinatier, le laboratoire de pharmacologie-toxicologie des Hospices Civils de Lyon et l\u2019Institut des Sciences Pharmaceutiques et Biologiques de Lyon. Cette coop\u00e9ration couvre l\u2019analyse des caract\u00e9ristiques gal\u00e9niques et les dosages par des techniques analytiques de laboratoire \u00e0 haute pr\u00e9cision pour mesurer la quantit\u00e9 de principe actif.<\/p>\n
Ces travaux prolongent une premi\u00e8re \u00e9tude d\u00e9j\u00e0 conduite au Vinatier sur la stabilit\u00e9 de la clozapine apr\u00e8s d\u00e9conditionnement, publi\u00e9e en 2024 dans l\u2019European Journal of Hospital Pharmacy (Emonet et al.). Cette \u00e9tude avait montr\u00e9 que les comprim\u00e9s de clozapine 100 mg Viatris conservaient leur stabilit\u00e9 apr\u00e8s d\u00e9conditionnement (d\u00e9tail non int\u00e9gralement repris dans l\u2019extrait). Les r\u00e9sultats actuels sur l\u2019aripiprazole et la sertraline ne sont pas encore pr\u00e9sent\u00e9s dans le texte, ce qui limite \u00e0 ce stade les conclusions op\u00e9rationnelles. Les enjeux de politique publique identifi\u00e9s concernent principalement l\u2019optimisation des pratiques de dispensation hospitali\u00e8re, l\u2019am\u00e9lioration de la tra\u00e7abilit\u00e9 et de la s\u00e9curit\u00e9 des traitements tout en r\u00e9duisant le gaspillage m\u00e9dicamenteux et les contraintes de fonctionnement, dans un contexte de g\u00e9n\u00e9ralisation de la dispensation nominative automatis\u00e9e.\u00a0(contenu r\u00e9sum\u00e9 en fran\u00e7ais par l’IA)\u200bLire la Suite<\/a>\u200b<\/p>","protected":false},"excerpt":{"rendered":" Des pharmaciens de l\u2019h\u00f4pital psychiatrique du Vinatier (France) m\u00e8nent le projet \u00ab \u00c9tudes de Stabilit\u00e9 des M\u00e9dicaments Reconditionn\u00e9s \u00bb (ESMR), visant \u00e0 produire des donn\u00e9es scientifiques sur la stabilit\u00e9 de […]<\/p>\n","protected":false},"author":1,"featured_media":4388,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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