Une \u00e9quipe de recherche fran\u00e7aise (Inserm, Institut Pasteur, Universit\u00e9 Lyon 1, Centre L\u00e9on-B\u00e9rard) a publi\u00e9 dans la revue BMC Medicine des travaux pr\u00e9liminaires portant sur le diagnostic de l\u2019endom\u00e9triose \u00e0 partir de sang menstruel. L\u2019endom\u00e9triose est d\u00e9crite comme une affection fr\u00e9quente touchant environ 10 % des femmes, caract\u00e9ris\u00e9e par la pr\u00e9sence de tissu de type ut\u00e9rin en dehors de l\u2019ut\u00e9rus, avec des sympt\u00f4mes incluant douleurs menstruelles et pelviennes chroniques, troubles gastro-intestinaux, douleurs lors des rapports sexuels et infertilit\u00e9. Le d\u00e9lai moyen de diagnostic est indiqu\u00e9 \u00e0 sept ans.<\/p>\n
Historiquement fond\u00e9 sur la chirurgie avec pr\u00e9l\u00e8vement de tissus, le diagnostic repose d\u00e9sormais principalement sur l\u2019imagerie m\u00e9dicale, jug\u00e9e fiable mais limit\u00e9e par la difficult\u00e9 \u00e0 d\u00e9tecter de petites l\u00e9sions et par le faible nombre de sp\u00e9cialistes disponibles. Le texte souligne ainsi un enjeu majeur de sant\u00e9 publique : la n\u00e9cessit\u00e9 de m\u00e9thodes diagnostiques plus rapides, non invasives et plus accessibles.<\/p>\n
Dans ce contexte, les chercheuses et chercheurs se sont int\u00e9ress\u00e9s au sang menstruel comme source potentielle de biomarqueurs diagnostiques. Ce sang, issu de la d\u00e9gradation cyclique de l\u2019endom\u00e8tre en l\u2019absence de f\u00e9condation, contient des cellules de type ut\u00e9rin (\u00e9pith\u00e9liales, stromales, endoth\u00e9liales, immunitaires). L\u2019\u00e9tude, men\u00e9e notamment par Camille Berthelot (Inserm, Institut Pasteur) et Axelle Brulport (Inserm, laboratoire des applications th\u00e9rapeutiques des ultrasons Inserm\/Universit\u00e9 Lyon 1\/Centre L\u00e9on-B\u00e9rard), a analys\u00e9 le sang menstruel de 10 utilisatrices de coupes menstruelles, \u00e2g\u00e9es de 18 ans et plus.<\/p>\n
Les r\u00e9sultats mettent en \u00e9vidence un ensemble prometteur de biomarqueurs li\u00e9s \u00e0 des diff\u00e9rences d\u2019expression g\u00e9nique, et montrent que les cellules \u00e9pith\u00e9liales pr\u00e9sentes dans le sang menstruel des personnes atteintes d\u2019endom\u00e9triose sont celles qui pr\u00e9sentent les diff\u00e9rences les plus marqu\u00e9es par rapport aux personnes non atteintes. Ces travaux restent pr\u00e9liminaires mais sont pr\u00e9sent\u00e9s comme ouvrant la voie au d\u00e9veloppement d\u2019outils diagnostiques plus rapides et non invasifs pour l\u2019endom\u00e9triose, ce qui pourrait, \u00e0 terme, contribuer \u00e0 r\u00e9duire les d\u00e9lais de diagnostic et am\u00e9liorer l\u2019acc\u00e8s au d\u00e9pistage. Les incertitudes tiennent au caract\u00e8re exploratoire et encore limit\u00e9 de l\u2019\u00e9tude (nombre restreint de participantes, d\u00e9marche principalement m\u00e9thodologique).\u00a0(contenu r\u00e9sum\u00e9 par l’IA)\u200bLire la Suite<\/a>\u200b<\/p>","protected":false},"excerpt":{"rendered":" Une \u00e9quipe de recherche fran\u00e7aise (Inserm, Institut Pasteur, Universit\u00e9 Lyon 1, Centre L\u00e9on-B\u00e9rard) a publi\u00e9 dans la revue BMC Medicine des travaux pr\u00e9liminaires portant sur le diagnostic de l\u2019endom\u00e9triose \u00e0 […]<\/p>\n","protected":false},"author":1,"featured_media":4209,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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