Une \u00e9tude internationale associant l\u2019Institut Max-Planck de biologie \u00e0 T\u00fcbingen (Allemagne), l\u2019Universit\u00e9 de G\u00e9orgie (\u00c9tats-Unis), l\u2019Institut Pasteur, l\u2019Inserm, l\u2019Universit\u00e9 du Manitoba (Canada), l\u2019Universit\u00e9 de Californie \u00e0 San Diego (\u00c9tats-Unis) et l\u2019Institut de m\u00e9decine tropicale de l\u2019Universit\u00e9 de T\u00fcbingen met en \u00e9vidence le r\u00f4le du microbiome intestinal dans la r\u00e9ponse immunitaire \u00e0 la vaccination. Les chercheurs montrent que la s\u00e9v\u00e9rit\u00e9 des fi\u00e8vres post-vaccinales varie en fonction de la composition du microbiome intestinal des individus, caract\u00e9ris\u00e9 avant l\u2019injection.<\/p>\n
Les travaux indiquent en particulier que la pr\u00e9sence de flagelline, une prot\u00e9ine bact\u00e9rienne, est associ\u00e9e \u00e0 une fi\u00e8vre plus marqu\u00e9e apr\u00e8s la vaccination. L\u2019alimentation appara\u00eet comme un d\u00e9terminant important de la production de flagellines par le microbiome intestinal et, par cons\u00e9quent, de l\u2019intensit\u00e9 de la r\u00e9ponse post-vaccinale. L\u2019\u00e9tude, dont la publication dans la revue Science est annonc\u00e9e pour le 8 octobre, apporte ainsi un \u00e9l\u00e9ment d\u2019explication aux diff\u00e9rences interindividuelles de r\u00e9actions, notamment f\u00e9briles, apr\u00e8s vaccination, alors que ces variations n\u2019\u00e9taient pas explicit\u00e9es jusqu\u2019\u00e0 pr\u00e9sent.<\/p>\n
Ces r\u00e9sultats sont d\u2019int\u00e9r\u00eat pour les politiques de sant\u00e9 publique, dans la mesure o\u00f9 la crainte des effets secondaires, en particulier la fi\u00e8vre, peut freiner le recours \u00e0 la vaccination et contribuer \u00e0 une baisse des taux de couverture, avec un risque accru de maladies et de d\u00e9c\u00e8s \u00e9vitables. Les donn\u00e9es soulignent le r\u00f4le potentiel du microbiome et de l\u2019alimentation comme facteurs contextuels de la tol\u00e9rance vaccinale, sans toutefois proposer, \u00e0 ce stade, de mesure op\u00e9rationnelle ou de recommandation sp\u00e9cifique pour les syst\u00e8mes de sant\u00e9.\u00a0(contenu r\u00e9sum\u00e9 par l’IA)\u200bLire la Suite<\/a>\u200b<\/p>","protected":false},"excerpt":{"rendered":" Une \u00e9tude internationale associant l\u2019Institut Max-Planck de biologie \u00e0 T\u00fcbingen (Allemagne), l\u2019Universit\u00e9 de G\u00e9orgie (\u00c9tats-Unis), l\u2019Institut Pasteur, l\u2019Inserm, l\u2019Universit\u00e9 du Manitoba (Canada), l\u2019Universit\u00e9 de Californie \u00e0 San Diego (\u00c9tats-Unis) et […]<\/p>\n","protected":false},"author":1,"featured_media":4209,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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