Une analyse g\u00e9nomique de l\u2019\u00e9pid\u00e9mie de maladie \u00e0 virus Bundibugyo (BDBV) d\u00e9clar\u00e9e le 15 mai 2026 \u00e0 Bunia, en Ituri (R\u00e9publique d\u00e9mocratique du Congo \u2013 RDC), montre qu\u2019elle est li\u00e9e \u00e0 un variant distinct de ceux \u00e0 l\u2019origine des flamb\u00e9es de 2007 et 2012. Les r\u00e9sultats sont compatibles avec un nouvel \u00e9v\u00e9nement de transmission zoonotique, et non avec la r\u00e9surgence d\u2019un virus d\u00e9j\u00e0 circulant localement. Il s\u2019agit de la 17e \u00e9pid\u00e9mie d\u2019Ebola r\u00e9pertori\u00e9e au total et de la troisi\u00e8me attribu\u00e9e au virus Bundibugyo, mais c\u2019est la premi\u00e8re fois que la r\u00e9gion de Bunia et de l\u2019Ituri est affect\u00e9e par cette souche, les pr\u00e9c\u00e9dentes \u00e9pid\u00e9mies locales, notamment celle de 2018\u20132020, \u00e9tant li\u00e9es au virus Ebola Za\u00efre (EBOV).<\/p>\n
L\u2019identification de la souche Bundibugyo a \u00e9t\u00e9 r\u00e9alis\u00e9e \u00e0 l\u2019Institut national de recherche biom\u00e9dicale (INRB) de Kinshasa, laboratoire national de r\u00e9f\u00e9rence de la RDC pour les agents pathog\u00e8nes \u00e9mergents et r\u00e9\u00e9mergents. Des analyses compl\u00e9mentaires par PCR et s\u00e9quen\u00e7age m\u00e9tag\u00e9nomique enrichi en virus ont \u00e9t\u00e9 men\u00e9es apr\u00e8s que les premiers cas suspects avaient \u00e9t\u00e9 test\u00e9s n\u00e9gatifs au virus Ebola Za\u00efre par le test GeneXpert utilis\u00e9 dans le laboratoire provincial. Les chercheurs ont analys\u00e9 par PCR et s\u00e9quen\u00e7age le g\u00e9nome viral \u00e0 partir d\u2019\u00e9chantillons sanguins et oropharyng\u00e9s de personnes infect\u00e9es en RDC et en Ouganda, puis compar\u00e9 ces s\u00e9quences avec celles des virus Bundibugyo responsables des \u00e9pid\u00e9mies de 2007 et 2012, dans le cadre d\u2019une analyse phylog\u00e9n\u00e9tique visant \u00e0 pr\u00e9ciser les relations \u00e9volutives entre les souches.<\/p>\n
L\u2019\u00e9pisode met \u00e9galement en \u00e9vidence une transmission transfrontali\u00e8re entre la RDC et l\u2019Ouganda, confirm\u00e9e par un cas diagnostiqu\u00e9 en Ouganda chez une personne ayant voyag\u00e9 depuis Bunia. Ce cas concerne un ressortissant k\u00e9nyan r\u00e9sidant en RDC, tomb\u00e9 malade environ un mois auparavant, ayant consult\u00e9 plusieurs \u00e9tablissements de sant\u00e9 en RDC avant d\u2019entreprendre un trajet d\u2019environ 3 000 km \u00e0 travers l\u2019Afrique de l\u2019Est, \u00e0 la recherche d\u2019une meilleure prise en charge ou pour rentrer dans son pays, tout en franchissant sans d\u00e9tection les diff\u00e9rents contr\u00f4les thermiques et sanitaires aux fronti\u00e8res et dans les a\u00e9roports. Cet \u00e9l\u00e9ment souligne des limites op\u00e9ratoires des dispositifs de contr\u00f4le sanitaire aux fronti\u00e8res et illustre les enjeux li\u00e9s aux mobilit\u00e9s r\u00e9gionales dans la gestion des \u00e9pid\u00e9mies \u00e0 virus \u00e9mergents.\u00a0(contenu r\u00e9sum\u00e9 par l’IA)Lire la Suite<\/a>\u200b<\/p>","protected":false},"excerpt":{"rendered":" Une analyse g\u00e9nomique de l\u2019\u00e9pid\u00e9mie de maladie \u00e0 virus Bundibugyo (BDBV) d\u00e9clar\u00e9e le 15 mai 2026 \u00e0 Bunia, en Ituri (R\u00e9publique d\u00e9mocratique du Congo \u2013 RDC), montre qu\u2019elle est li\u00e9e […]<\/p>\n","protected":false},"author":1,"featured_media":4499,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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